Paroxetine (Paxil) for PTSD

How Does Paroxetine Work for PTSD?
PTSD is associated with dysregulation of the brain’s fear circuitry, particularly involving the amygdala (fear processing), hippocampus (memory contextualization), and prefrontal cortex (emotional regulation). Serotonin plays a critical modulatory role in these regions.

By inhibiting the reuptake of serotonin at the synaptic cleft, paroxetine:

Enhances serotonergic signaling

Reduces hyperreactivity of the amygdala to threat cues

Gradually dampens the exaggerated stress response

This effect is not immediate. Patients typically require 4 to 8 weeks at a therapeutic dose to experience meaningful symptom reduction.

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Categories: ADHD MEDICATIONS, PTSD MEDICATIONS
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